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  • Main Subject - Gordon Brown's Bold Budget - 21st March 2007

    Economists have suggested that Mr Brown gave with one hand and took away with the other in this budget. Gordon
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    Brown certainly wrong-footed the political opposition when he pulled his income tax cut out of the hat in the l
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    st few minutes of his budget speech. The main budget changes are:

    Financial
  • The basic rate of inco
  • lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    e tax to fall from 22p to 20p - April 2008
  • Top rate income tax threshold raised to ?43,000 - April 2009 <
  • here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    i>Corporation tax reduced to 28% from 30% - April 2008
  • Small companies tax rate raised from 20p to 22p -20
  • d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    9
  • Capital gains tax exemption rises from ?8,000 to ?9,200 - ?18,400 for a married couple
  • Inheritance
  • ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    ax allowance rises from ?285,000 to ?350,000 - April 2008
  • Child benefit for first child rises to ?17.45 an
  • easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    to ?20 by 2010
  • Tax-free allowance for pensioners under 75 raised from ?7,280 to ?9,770 - 2011

    Environ
  • nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    ental
  • Raised road tax for gas-guzzling cars (Band G rises to ?300 and to ?400 in April 2008)
  • Lowe
  • and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    t emission cars remain at zero tax and Band B tax reduced to ?35
  • Zero-carbon new homes up to ?500,000 made
  • ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    exempt from stamp duty up to
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    2012
  • Annual land-fill tax raised ?8 - April 2008
  • Grants of ?300-?4,000 for pensioners installing insu
  • dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    ation/central heating in homes

    Luxuries
  • Beer and cider up 1 pence a pint, wine up 5 pence a bottle
  • cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    sparkling wine up 7 pence - from midnight 25 March 2007
  • Cigarettes up 11 pence a packet - 6pm tonight
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    >No increase to spirits
  • Cut in VAT on nicotine replacement therapies for 1 year from July - (from 17.5 per
  • t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    el, but he added no VAT to airline tickets and business owners were disappointed with the rise in small busines
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    tax, but overall the budget was judged as fair. As predicted Brown concentrated on the environment and educati
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    n. There is to be a ?14 billion increase in spending on schools - a rise from ?60 billion to ?74 billion by 201


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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