Main Subject - Internet and Businesses Online

What was that about? Three messages in a row from people I had never heard of asking me to stop

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

spamming them amidst the usual pile of spam. I never sent any spam messages. Or did I?

Unfor

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

unately it is quite possible, even quite easy, to fake the sender of a message. While the simpl

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

techniques will not fool a serious inquiry, they can certainly make it look at first glance as

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

f it is you that is sending out these spam messages by the hundred. It's a rather annoying var

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

iation of a "Joe Job Attack". This is, if you like, Joe Job Spamming, and it works as follows:

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

Regular spammers build up a massive list of email addresses and spam them at will. The deriviti

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

e of this is not only to use these addresses in the to: line, but also in the from: line. It's

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ike 2 for the price of one spam. If the address is incorrect or invalid it bounces back to anot

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

her spam attack address, often with the initial message intact.

So, what can be done to stop th

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

s form of spam? There's really not a huge amount that can be done inside the current framework.

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

What IS required is an overhaul of the framework. Without getting into a comp

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ete history of email it started with companies/universities being able to use an internal messag

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ing system. In these environments abuse was rare and usually easily located. For convenience s

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ke these institutes started linking their systems so you could send email not only to your colle

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

gues at the same location as you, but to nationwide branches also. Like the internet, email pro

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ocols grew out of a number of smaller nets linking together. It was not so much designed, as it

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

happened.

Perhaps it is time to overhaul the system completely. One thing is certain and that

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

is that the ability to send e-mail anonymously has a single benefactor - and that is spammers.

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

f we want to get serious in fighting spam - we must remove the ability to anonymously send email

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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