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When I began my anti spam crusade, I had assumed that most people online could competently do things such as set up a spam filter in Microsoft Outlook or Outlook Express.

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

It turns out this is not so, the fear of making adjustment to the default settings getting the better of quite a majority of the population, or else just never having t

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

e time or inclination to get in and figure it out.

Luckily it is quite an easy process, and even the most computer-ese challenged amongst us can get it done easily once

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

e understand how to it works. In this little how-to I am going to give an example how to set up a filter using Outlook Express, purely on the basis that this is the prog

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

am open on my desktop as I type this.

There are two parts to a filter - a condition, and an action. The condition defines the set of circumstances that will trigger the

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

action. The action is of course what happens when the circumstances described in the condition are true.

The example I will use here is to delete messages with [SPAM] i

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

n the title. My ISP once went through a rather silly phase of not deleting spam - but marking it in the header and leaving the deletions to us. It seems they too had ma

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

e an assumption that all their customers could set up a filter to handle the hundreds of [SPAM] marked messages they suddenly started receiving. They were quickly put ri

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ht but overloaded switchboards.

So we are going to create a simple filter in Outlook Express that deletes everything with [SPAM] in the title.

Step 1: Click on the

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

enu Item Tools. Point at Message Rules and select(click on) mail... A small new window will open with the heading Message Rules and three tabs. The Mail... tab

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ill be selected.

Step 2: Click on the New... button. Another new window opens with the titlebar New Mail Rule. There are 4 boxes to fill in.

Ste

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

p 3: In the first white box Click in the square beside "Where the Subject line contains specific word". A tick will appear in the box. You will notice the 3rd b

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

x gets some more writing in it, we will deal with that soon.

Step 4: In the second white box click in the square next to Delete It. A tick will appear in

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

the box. The text in the third white box will now read: Apply this rule after the message arrives, Where the Subject line contains specific words, Delete it. The words

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

'contains specific words will be blue and underlined.

Step 5: In the third white box click on the blue underlined words 'contains specific words'. A new

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

indow will open with the title bar Type Specific Words.

Step 6: In the first box in this window type [SPAM]. Click Add. Click Okay. You will be returne

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

d to the previous window. The third box will now contain the text: Apply this rule after the message arrives Where the Subject line contains '[SPAM]' Delete it

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

tep 7: In the fourth Box type a userfriendly name for your spam filter. I use "Delete [SPAM] rule". Click the OK button. After clicking okay you are taken back

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

to the message rules window. Click OK here and your filter is added. Well Done.

As far as I am aware there is no limit to the number of filters you can apply. The

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

important thing to remember is that the filter doesn't discriminate. If the result returns true then the action (Deleting in this case) will be applied.

Happy filtering

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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