Main Subject - Internet and Businesses Online

Those who use webmails such as Yahoo, Gmail and hotmail will have noticed a spam message fo

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

lder. This is the folder where messages the email provider suspects as spam are sent, stor

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

d for a month or so and then deleted. Most of the time people will not go into this folder

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

at all, because the messages they do want are directed the the inbox. Sometimes however me

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

sages are falsely labelled as spam and dropped into this folder, and unless the user is spe

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ifically expecting that message, they usually won't even know.

The program that does this

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

utomatic sorting with such a high success rate is known as a Bayesian Filter, and it actual

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ly runs a series of ingenious tests on the titles and content of each email it sees to dete

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

mine it's status. Words are assigned a score based on their 'spamliness' and the entire me

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

sage is then given a 'spam percentage'. Where bayesian Filters are so effective is that th

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

y can learn what sort of mail you like and don't like and personalise themselves to you. T

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ey then allow you to choose the level of security you would like. The levels are basically

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

defined by what score of 'spam percentage' constitutes spam. For instance if the filter de

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ects a message is 50% likely to be spam this may be flagged as spam on high level security,

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

but not on Medium level.

Webmails have the added advantage of having a huge pool of custo

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ers information to draw from. If the first 50 people to receive a message flag it as spam

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

hile no-one passes it, that message will start receiving higher and higher spam scores as i

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

is delivered to other users.

Another beauty of a bayesian filter is that most of the time

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

you will never know it is there. It cleans your incoming mail before you ever see it, leav

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ng you with (mostly) non spam messages in your inbox after taking out all the (mostly) spam

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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