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    As with every other business, search engines are fighting to have a good market share by providing their visitors with relevant and useful inf
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    ormation. Google as a leading search engine provider is working to improve its search results by continuously updating its algorithms to provi
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    e its visitors with relevant, useful and fresh information. One of the technologies, Google uses in its algorithm to provide users with releva
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    nt information is Latent Semantic Indexing (LSI).

    What is Latent Semantic Indexing?

    Latent Semantic Indexing (LSI) is an information retriev
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    l technology that retrieves information from websites and information repositories based on the vector space model of document classification.
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    Through the use of LSI technology, relevant information can be retrieved from a collection of documents based on its meaning or concept, even
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    if the document does not have the search word.

    Latest semantic indexing allows a search engine to determine a relevancy of a page not only w
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    th its search query, but also with the context of the search query. In other words, LSI helps search engine to retrieve data based on the cont
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    ext of the search query. For instance, Search engine are able to identify “Laptop” and “Notebook computer” are similar conceptually.

    Google h
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    s long been using Latent Semantic Indexing for adsense to display relevant advertisement on adsense publisher’s websites. Undeniable evidence
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    uggests that Google is also giving LSI more emphasis in its search algorithm to provide its visitors with relevant information.

    How To Determ
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    ine Which Words Are Semantically Identical?

    In order to find words, which are semantically similar to a given word, do a search in Google usi
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    g a tilde (~) function. Google with automatically pull the result, with semantic words bolded. For Instance, if you want to search for words s
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    emantically related to car, insert ~car into Google search box. The semantically related words will appear bolded in the search result. The fo
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    lowing words are semantically related to a keyword “Car”.

    Cars

    Auto

    Automobile

    Automotive

    And for the search ~Laptop

    Laptops

    Notebook

    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    omputer

    Notebook Computers

    Laptop Computers

    Importance Latent Semantic Indexing

    Google uses latent semantic Indexing to combat spamming an
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    d provide its customers with relevant, useful and fresh information. It is believed that, Google is implementing LSI in its algorithm for the
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    ollowing tasks:

    1. Provide its customers (searchers) with relevant and useful information;

    2. Identify poor quality websites (content wise);
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de


    3. Identify duplicate content;

    4. Examine link profile.

    Summary

    As search engine, like Google are giving latent semantic indexing more em
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    hasis in providing its searchers with useful and relevant information, it is important to design LSI friendly websites to get a good page rank


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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