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    One of the factors that constitute the (high) value of search engines is the data gathering process behind the search. With this they are
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    able to produce information and knowledge. This information reveals human (search) behavior, but most of all it reveals search trends.

    Th
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    e most commonly known analysis methods in financial (investment) analysis are technical and fundamental analysis. The fundamental analyst
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    bserves the stock values on bases of company analysis. The technical analyst (TA) is less involved with the collateral value but merely in
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    terested in the trends of the stock-price.

    The interesting aspect of TA is that it provides you a signaling system. Without knowing the c
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    use you are signaled which stocks (bonds, currencies, etc) move in what direction. Take care however with TA, because it is said that TA i
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    s like looking outside the rear-window of a van and signaling the driver which way to go to.

    If you observe the search market and
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    specially the demand for search you can in the same way signal search trends. To give an example with data from Overture on “management”:
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    • June 2004 -- about 2,000,000 searches of which 150 different types (with “investment management” being the highest with about 1
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    0,000 searches)
  • December 2005 – about 2,200,000 searches of which 100 different types (with “property management” being the high
  • ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    est with more than 200,000 searches)

    Doing such an analysis is nearly impossible without the services from the mayor search e
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    ngines. First you need to know the overall search growth on all the entries in order to get the main index (to serve as a benchmark). And
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    lso two measures are never sufficient to “calculate” a trend.

    Yet this analysis, how simple or profound as you might want to pursue it, s
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    hows interesting information;

    Although searches on management show a stable horizontal trend (in absolute figures, perhaps relatively spo
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    en the trend could be descending), the changes between different types of management are significant. To give some examples:
    • Ch
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    ange management from about 14,000 in June 2004 (21,000 May 2005) to about 11,000 (December 2005)
  • Performance management from abo
  • ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    t 11,000 (16,000 in May 2005) to about 70,000 (December 2005)
  • Property management from 130,000 to about 240,000 (December 2005)<
  • y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    /li>

    A next step would be to add the fundamental part to the analysis. What is the drive behind these changes? This simple demonstra
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    ion is focused on management, but you could apply this to any area. “Ask” you search engine for data or start with a simple analysis yours
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    elf.

    For SEO the trend analysis could help you in anticipating changes. Just take care to turn left at the right moment.

    © 2006 Hans Boo


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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