Main Subject - Internet and Businesses Online

Pay per click (PPC) is an advertising technique used on websites, advertising networks, and search engines. Pay per click search engines has become an integrated part of search engine optimization. They are

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

all based on the auction principle. You make a bid for a certain keyword or keyword phrase, and the amount decide the ranking.

Pay per click advertising on search engines allows you choose keywords you would like

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

our site to appear for when a search is performed. You decide how much you are willing to pay each time a person clicks on the search results. The more you are willing to pay per click, the higher your site will ap

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ear in the results for the keywords you choose.

By searching,there are hundreds of pay per click search engines,but the most popular are Google AdWords and Yahoo! Search Marketing (formerly Overture). Depending on

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

the search engine, prices per click is between US$0.01 and US$0.50. Very popular search terms can cost much more on popular engines. Abuse of the pay per click model can result in click fraud.

Parties Involved<

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

b>

In this area, a publisher is a webmaster that displays ads from the advertiser.In order to bring together advertisers and publishers,a number of advertising networks where established. they are often search eng

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

nes, who already had many advertisers as clients, who they could link up with other publishers. The advertising network collects the money from the advertisers, and passes a portion onto the publisher.

Google is a

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

n example of this. Often these combined search engines and advertising networks,are referred to simply as PPC engines.

Categories

PPC engines can be categorized in "Keyword", "Product", "Service" engines.

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

However, a number of companies may fall in two or more categories. More models are continually evolving. Currently, pay per click programs do not generate any revenue solely from traffic for sites that display the

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ds. Revenue is generated only when a user clicks on the ad itself.

- Keyword PPCs

Advertisers using these bid on keywords, which can be words or phrases, and can include product model numbers. When a user

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

earches for a particular word or phrase, the list of advertiser links appears in order of bidding. Keywords, or search terms, are the very heart of pay per click advertising.

There are hundreds of Keyword pay per

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

lick search engines. Notable PPC Keyword search engines include: Google AdWords, Yahoo! Search Marketing (formerly Overture Services), Microsoft adCenter, LookSmart, Miva (formerly FindWhat), Ask (formerly Ask Jeev

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

s), 7Search, Kanoodle, and Baidu.

- Product PPCs

Product engines engines are also called Product comparison engines or Price comparison engines. Product engines let advertisers provide "feeds" of their pro

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

uct databases and when users search for a product, the links to the different advertisers for that particular product appear, giving more prominence to advertisers who pay more, but letting the user sort by price t

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

o see the lowest priced product and then click on it to buy.

BizRate.com, Shopzilla.com, NexTag, PriceGrabber.com, and Shopping.com,are noteworthy PPC Product search engines from hundreds of them.

- Service PP

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

s

Service engines let advertisers provide feeds of their service databases and when users search for a service offering links to advertisers for that particular service appear, giving prominence to advertisers

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

who pay more, but letting users sort their results by price or other methods. Some Product PPCs have expanded into the service space while other service engines operate in specific verticals.

Some of the PPC servi

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

es include NexTag, SideStep, and TripAdvisor.

- Pay per call

Similar to pay per click, pay per call is a business model for ad listings in search engines and directories that allows publishers to charge lo

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

al advertisers on a per-call basis for each lead (call) they generate. The term "pay per call" is sometimes confused with "click to call". Click-to-call, along with call tracking, is a technology that enables the “

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ay-per-call” business model.

Pay-per-call is not just restricted to local advertisers. Many of the pay-per-call search engines allows advertisers with a national presence to create ads with local telephone numbers

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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