Main Subject - Internet and Businesses Online

Wow! I just finished sending out my ezine and I'm exhausted. For something I do for free and is suppose to be a labor of love, it sure has turned into a full-time job.

When I started ezine publishing about five years ago, it wa

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

s fun. You could send out a mailing by 9:00 and have sales rolling in by noon. It's not like that anymore. Heck, sometimes you wonder if half of your subscribers are even getting your ezine, let alone taking the time to actual

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ly read it. And to what do we owe this pleasure to? Email filtering. Yes, that's right -- filtering (which was started to keep out that "4 letter word" I can't even print for fear this article will go straight to your trash bi

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

n) has made every ezine publisher across the globe jump through hoops to make sure their issues are getting through. It's funny, the "improve your love life" and "grow your body parts" emails still show up like clockwork, but

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

the ezines I opted in to receive get trashed. Go figure.

I still publish in text format but you'll find a lot of publishers publishing in HTML. Sure, it looks pretty, but with HTML email many times it's blocked by the end user

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

or interpreted to be "junk mail." It has a higher chance of being "killed" as it's often seen as a possible virus by many virus checking programs.

Some say why not publish in PDF and send it out as an attachment? Again, not

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

something filters like. Attachments may be a virus, so again, your message may be deleted before hitting your subscribers' inboxes. Also, PDF files are usually quite large in size, which many subscribers may not like clogging u

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

p their mailboxes.

So what's a publisher to do? Many have taken the high road and stopped publishing altogether. But if you have a passion for publishing and really like to help people, that's not an option. I love creating my

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ezine even if sending it out means I have to perform a few tricks. Besides, I'm not quite ready to let the "bad people" chase me out. If we stop publishing, they win.

Here are some publishing tips to help you maneuver your e

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

zine through the filters:

1) After creating your ezine, run it through a software program that will check it for "trigger words" and try to modify it or tone it down. If you're getting a high score try changing some of your wo

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

rding. Make sure to test your subject line too. Two that I use for checking:

http://EzineChecker.com
http://tinyurl.com/ejjz

2) Send in text format only. If you want to reproduce it in HTML format then you need to make an

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

HTML version of your newsletter and post it online. Please don't just send a link to your list telling them where to go to read the latest issue. Studies show they won't. People are basically lazy and if they have to work to

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

read your ezine chances are they won't. They signed up to get your information in their "inbox" make sure you give it to them. Is it more work making dual formats of your ezine? Yes, it is. But, if you want to make sure your m

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

essages are being read, it's important.

3) After sending out the text version of my newsletter I wait 24 hours and send a second notice out informing them it was sent out along with a link to where they can read it online (th

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

e HTML issue link) in case the first issue never made it to their inbox. The 2nd issue will almost surely pass the filters as it contains no "trigger words". Again, watch your subject line.

4) You should also offer an alternat

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ive reading method like http://NewsMon.com Easy to set up and free and just takes one line of text to update it.

5) Ask your subscribers to "whitelist" whatever email address your publication comes from. This will ensure it's

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

not sent to the trash upon receipt. If you have to send out a notice by itself asking your readers to do this to insure future issues will arrive safely in their inbox.

6) Remember to remove hard bounces from your list. Word

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

has it that continually sending out bouncing email to certain ISP's can get you banned from that particular server. Soft bounces due to full mailboxes will happen, hard ones need to be removed immediately.

So there you have i

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

t. Now you know why I'm so tired. What used to be finished in just one click has turned into a 2-day affair. If you're serious about publishing an ezine and you're not just in it for the money, you'll need to take these extra

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

steps to make sure your ezine is getting through to your subscribers.

Remember, "neither rain, nor snow, nor sleet nor filters" will stop a good newsletter from getting through. Now excuse me, I have to go and clean up my list

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Many businesses and business people care assiduously about processes... Many other businesses care little about processes. When they try to map their processes they get confused between activities, KPIs, processes, policies and parameters.

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Main Subject - Ezine Publishing: It Ain't What It Use to Be

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