Main Subject - Business

Last week I told you about a recent report from The Conference Board that has a lot of big company CEOs concerned about competition from smaller, more innovative and entrepreneurially-minded companies. To refresh your memory, The Conference Board's CEO Challenge 2004 reported that 87% of the 540 global businesses surveyed cited innovation and enabl

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ing entrepreneurship as priorities for their companies, and 31% considered these issues of "greatest concern."

These CEOs understand that their big company status no longer guarantees that they will win contracts and retain market share based solely on their size and track record. They understand that the greatest threat to their businesses is not

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

coming from the boardrooms of their largest competitors, but from small companies born in garages, on kitchen tables, and in tiny, rented offices.

It's a fact that smaller companies, by need and design, are more innovative, more flexible, more decisive, and faster to move than their larger brethren who are entrenched in operational processes and c

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

orporate procedures. Small companies are typically not led by career executives for whom every decision must be predicated by hours of meetings and mounds of documentation. Most small companies are led by their founders; men and women who were cut from an entrepreneurial cloth that has yet to fade. It is when a company grows to the point that the

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

founder steps aside to make way for professional managers that the company loses its innovative nature and entrepreneurial flair.

The good news for large companies is that they have definite advantages over small companies, especially when it comes to resources and funding. Turning a Goliath into a raging horde of David's is never easy, but it ca

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

be done if the company is willing to make changes to internal processes and attitudes, and commit the time, money, and personnel to make it happen.

Since size and number of years in business are no longer differentiators in the competitive marketplace what must large companies do to become more innovative and entrepreneurial? To begin they must

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

do three things: shorten the process time, cut through the red tape, and promote innovative and entrepreneurial thinking from the top down. If the board, the CEO, executives, managers, supervisors, and employees are not dedicated 100% to making the changes necessary to transform the company, the effort will fail and the giant will lumber on.

Short

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

en The Process Time

At large companies everything is done by the book, i.e. by established processes and procedures. Very little gets done at large companies without what I call the "Multiples of M." Multiple Meetings to discuss the issue; Multiple Memos to reiterate the issue; and Multiple Management approvals required to sign off on the issue.

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

To become more innovative and entrepreneurial large companies must streamline the decision-making process down to a single set of M's: Move on or Make it happen.

Cut Through The Red Tape

Here's a true example from my corporate days that illustrates how procedures and red tape get in the way of efficient operations A fluorescent bulb in my office

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

blew, which made the other bulb in the fixture flicker like a strobe light at a discotheque (causing flashbacks that we won't discuss). I assumed getting a new bulb would be a simple matter of calling down to the facilities office and reporting the problem. My assumption was wrong. I was told that I would have to come to the facilities office, w

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ich was in another building 2 miles away, fill out a facilities request form, and take the form back to my immediate supervisor, who was required to stick his head in my office to confirm that the bulb was indeed out before signing the form. I assume this was to make sure that I was not trying to commandeer a fluorescent bulb under false pretenses.

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

Once my supervisor confirmed that I really did need a new bulb, he signed the form and I took it back to the facilities office, foolishly thinking that they would hand me a bulb that I could take back to my office. Oh no, that would have been too simple. I was told that once my form was approved by the facilities manager a maintenance worker woul

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

d be dispatched to my office and would replace the bulb for me. Great, I said. When can I expect that to happen?

"I can have someone over there a week from Tuesday between noon and 5pm," the man at the facilities desk replied. I suddenly felt like I was dealing with the cable company. How many big company employees does it take to change a ligh

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

t bulb? I lost count at four.

Encourage Innovation and Entrepreneurial Thinking

Next, you must create an environment in which innovation and entrepreneurial thinking are encouraged and rewarded. If your employees feel that their opinions, thoughts and ideas don't matter, they will not submit them to you, but may take them elsewhere.

Again, bas

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ed on my own experience, I can tell you that innovation, especially innovation that occurs below the management level, is often ignored, ridiculed, and in some cases, used as an excuse to give employees the boot. The perfect example of this was when I took an idea on how to improve an internal system to my manager and was told, "Knox, you think too

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

much." Now this was a new one on me. I had been accused of thinking too little and of not thinking at all, but never had I been accused of thinking too much. I do recall my dad telling me when I was young, "Son, if you had a brain you'd be dangerous." I suppose my manager was simply trying to relay the same message. "Shut up and go to your room

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

/cubicle like a good little boy/company drone before you get on my nerves and get spanked/fired." Within a few months I decided to take my overactive brain and put it to work for myself. After 10 years of business success, I think I made the right decision.

To promote innovation and entrepreneurship big companies must encourage everyone to think

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

like innovators and entrepreneurs. Make it a company policy that such thinking is required, expected and rewarded. Pose these questions: (1) How can we improve our current products and services; (2) What new uses can you think of for current products or services; (3) What new products and services can you think of that would be good additions to ou

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

r current offerings or perhaps even launch a new line; (4) What new opportunities do you see in the market place that might be worth pursuing?

Get Outside Help

Most large companies find it difficult to develop and implement an innovation plan simply because they refuse to devote the time and resources to getting it done. And since most executives

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

have never been entrepreneurs, they do not know how to encourage entrepreneurial thinking among their ranks. If your company needs help with innovation and entrepreneurship, bring in someone from the outside to direct and manage the effort for you.

You should never be embarrassed to ask for help, no matter how big you are.

Here's to your success

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

HTTP = HTML link (for blogs, profiles,phorums):
<a href="http://www.mainsubjects.org.ua/article/4963/mainsubjects-Teaching-The-Big-Boys-To-Think-Small.html">Teaching The Big Boys To Think Small</a>

BB link (for phorums):
[url=http://www.mainsubjects.org.ua/article/4963/mainsubjects-Teaching-The-Big-Boys-To-Think-Small.html]Teaching The Big Boys To Think Small[/url]

What you may not realize, especially if you are a beginner, is that you don't necessarily have to do business with a local commodity futures broker. In fact, you may even find it better to do business with a commodity futures broker that operates on a national level.

Business relationships need to provide you with the business you need. Whether you use an alliance, a leads group or a Power Team, you need to make sure that you are dealing with someone that is reliable, honest, and ethical.

Avoid it if the process is complicated or requires you to garner a certain number of points or make a certain amount of purchase to become eligible for cash back.

Tags

Links

Main Subject - Teaching The Big Boys To Think Small

Related Articles: