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These social and destructive insects live off wood, decay and dead leaf and plants. Although there are over three thousand species of

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

termites, there are three main groups called the subterranean, Formosan and drywood termites. These groups of termites have many dif

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ferent varieties and live in different parts of the country. Knowing the type of infestation you have is vital to eliminating your ho

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

me of an infestation.

Drywood Termites

This termite infests drywood and is a bit bigger than the subterranean termite. These termit

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

es have wings and fly from area to area because in search of food sources. The drywood termite lives above ground unlike the other tw

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

o groups of termites. This helps to identify them if you have an infestation in or around your home or building.

This termite lives

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

in rotted tree trunks, stumps and in some cases buildings. Because these termites live above ground, the destruction is noticed befor

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

e it become serious. If you spot a dry, powdery and smooth looking pellet piles by a wood structure, chances are you have an infestat

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ion of drywood termites. The termite pushes out the feces as they feed on the wood, leaving the evidence of infestation.

Subterranea

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

n Termites

The subterranean termite is found in many areas of the country. They also are the most damaging termite of all the specie

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

. They live underground and feed on wood. They search out their food source and tunnel into areas they find food supplies. The termit

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

e usually caused a great deal of damage before being detected. Repairing the damage made by the termite can amount to a sustainable a

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

mount of money.

Consuming up to fifteen pounds of wood a week, a single termite that goes undetected can eat you out of house and ho

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

me before you realize what the problem. Think about how much wood is consumed by thousands of termites. This makes their type of term

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ite the worst out of all the groups of termites. If one two by four weighs ten pounds, one termite can consume three two by fours in

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

three weeks while we know there are more than one termite, your house could be condemned in a matter of months.

Because they live un

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

derground, you may see worker termites in foundations and in some cases your furniture. Once they have their fill and now food left t

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

hey will move on to the next food source, maybe a neighbors home.

Formosan Termites

Not native to the United States, the Formosan t

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ermite originates in Asia and come to the states on wood products brought in by ships during the WWII. Many times home where built of

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

infested wood and the cost to the government was substantial to rid the homes of infestations. The termite lives underground as well

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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