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    Both Liquid Paper and Snugli were invented by moms as new solutions to old problems. Leveraging their ideas into successful products took different paths. Be smart about that business you’re cooking up at ho
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    me.

    Liquid Paper was invented by Bette Nesmith Graham to fix the smudges she made trying to erase typing errors at work.

    After a divorce in the 1940s, she combined her commercial art background with the need
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    to support herself and her small son Michael (later a member of the “Monkees” rock group) by devising the quick drying correcting fluid.

    Beginning with small batches in her blender, she gradually grew her bus
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    ness from her kitchen, to her garage, and eventually to a 35,000 square foot company plant with a child-care center and a library for employees.

    She kept secret the formula to what began as “Mistake Out” unti
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    her second marriage was breaking up in 1975. Fearful the trade secret would be lost, she applied for a patent on her formula and a trademark.

    Just months before her death in 1980, she sold the company she b
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    gan in her kitchen to the Gillette Corporation for $47.5 million (plus royalties until 2000). Royalties from Liquid Paper went towards a foundation she established to improve the welfare of women, and to othe
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    r philanthropies.

    The familiar Snugli fabric child carrier was created by Ann Moore for her own newborn after a stint in the Peace Corps where she observed the quiet, content babies carried in cloth carriers
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    y their African moms. Ann’s own mom, Lucy Auckerman, an experienced seamstress, refined and perfected the details.

    Their little cottage industry grew quickly, propelled by a commitment to extreme customer s
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    tisfaction.

    They patented the Snugli design in 1966, having the carriers sewn by local women, and then entered the manufacturing business in 1979 to meet customer demand.

    Years later, in 1985, when the paten
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    was soon to expire, they sold to to Gerry Baby Products, part of the Huffy Corporation (later purchased by Evenflo).

    In both cases, observation and experience provided insight for a new solution to an old pr
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    blem (Liquid Paper - erasing smudges and Snugli - transporting children). Both moms were smart about protecting their intellectual property by using a combination of legal strategies (trade secrets, trademark
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    s and patent protection) and smart business practices. Both were smart in starting their businesses in their homes and keeping their expenses low.

    Timing and “good luck” also played a role in their business
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    uccess.

    Liquid Paper came to market at the time of the IBM Selectric Typewriter – when correcting typing mistakes in the office was a common problem. The product was rejected by IBM. Orders resulted from an
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    rticle in an office trade magazine in 1958 and General Electric Company placed the first large order, for 400 bottles.

    Snugli, came to market in the 1960s as natural childbirth and breast feeding were becomin
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    popular. Adapting their product to the emerging culture of the time was indeed a masterful business strategy.

    In both cases, what started out as small home-based businesses turned into hughly successful bus
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    nesses from which the creators reaped the financial rewards for many years.

    So, about that business idea that you’re cooking up – ask yourself a few questions:

    -What problem does it solve?

    -Who will benefit
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    from your solution?

    -Why is your solution better than the alternatives?

    -How does it fit with the times?

    What steps can you take to protect your idea?

    -Be careful who you show it to (if possible, use a no
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    -disclosure agreement)

    -Is your approach unique and non-obvious? (consider a patent – 20 years of protection)

    -Is trade secret a better way to go? (no time limit as long as kept secret)

    -Can it be copyrig
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    t protected? (protects original works of authorship)

    -What about protecting the name? (register a trademark, domain name)

    Making money from your invention or creative work requires a combination of discipli
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    ed actions and “good luck.” The disciplined actions include using good business practices and legal protections. Good luck has a way of finding those who pursue opportunities with preparation and persistence


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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