Main Subject - Business

Distribution is the process of purchasing, storing, and distributing products when required. Whole

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

sale distribution is the process of purchasing the products directly from the suppliers or manufac

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

urers and reselling them to the retailers without transforming them in any way. They products are

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

tored in warehouses and sold when there is a demand.

Many wholesale distributors assemble, sort,

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ack and sell the goods they offer. This is called bulk breaking. The warehouse infrastructure requ

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

rement is based on the type of products stored. For example, pharmaceutical products require the p

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

oducts to be maintained at a certain temperature and wholesale distributors of pharmaceutical prod

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

cts must have a facility for refrigeration.

Apart from saving money for their customers, wholesal

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

distributors reduce risks to suppliers and customers by maintaining inventories. Their other func

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ions include quick delivery, financing customers through credits, supplying information about the

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

arket to the manufacturers, and bearing risks by absorbing the costs of damage.

Wholesale distrib

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

utors choose their target market. They then find profitable customers and build strong relationshi

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

s with them. They decide the inventory and maintain sufficient stock for immediate delivery. The g

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ods are purchased in bulk and hence the wholesalers pay low prices. Then they mark them up by a pe

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

centage. The wholesalers also promote their products apart from deciding the location of distribut

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

on. They sometimes promote their products using the reputation of their suppliers.

Over the last

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

en years, the wholesale industry in US has accounted for one quarter of the productivity improveme

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ts in the economy. Some wholesale distributors also offer drop ship facilities. Drop shipping invo

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ves shipping the products directly to the end customers. This allows retailers to get products at

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

holesale prices and focus their efforts on selling their products without worrying about logistics

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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