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    I've been working at a supermarket at a part-time basis and my managers have annoyed/bugged every once in a while, I guess they did it so I woul
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    dn't slacken off. During the last few weeks of my role in the supermarket (some coincidence this is) one of the managers that I wasn't familiar
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    with started picking on me. Of course from my past experience I know people can make mistakes so I gave him a few chances, oh yea did I say his
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    name is Lance? At first I thought he was picking on me because I came from a European background, later I found out he treated majority of the j
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    nior staff this way and I finally understood that he was doing it just because he could. It is people like these that can't be pitied.

    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    trong>What I did?

    He had used up his last chance and it was the last day I was working at the store and I had a plan if he was t
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    o come up to me looking for a fight. Nothing happened up until I was going home where he asked me a question and I unknowingly lied (due to fati
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    ue), it wasn't a big deal, it was only an empty box that I had forgotten to put away. As I passed by the box I realized what was going to happen
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    and what I was supposed to do. After 5 seconds of seeing the box Lance too saw the box and called out my name in a loud manner. Of course what
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    worse torture is there for someone who is obsessed with authority to not get a response from a junior staff especially when he's not bothering t
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    turn around to face you? By this time he was so mad that he was literally jogging to my back, he tried to threaten me once more by asking me wh
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    en I was going to work again and I responded by saying "never", as soon as I said that he was smiling thinking that I had quit because of him, I
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    wonder how he has reacted assuming that he has already found out that I resigned 2 weeks before!

    My recommendation to others
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    rong>

    A note of caution, do not, I repeat do not do anything silly towards your managers that you're going to regret later on. If there i
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    someone you can make a complaint to, do that first. If complaining doesn't work, think about if the job your doing is worth the mental stress,
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    if it is then argue back annoying comments and try to avoid your managers as much as possible. You might want to look for a few jobs once in a w
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    hile just incase the bullying gets too intense and unbearable.

    Also, even if you are planning on quitting your job make sure you have a b
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    ck-up plan for what you're going to do afterwards. Here's the juicy part, pick a day then think deep and hard on how you can get even with the m
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    anager that has bullied you for so long. If your manager is obsessive when it comes to authority like mine, you too can do something to disrespe
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    ct him and show him or her that their not the boss of you anymore so you could even sit on their special chair and put your feet onto their desk


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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