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  • Main Subject - Avoiding Pre-Press Headaches

    If you talk to printers and designers and you will hear horror stories from both about files that will not work no matter how they are saved, software version incompatibilities, proofing and printing problems, general miscommunication and more.

    Not only can pre-press problems cause delays in printing which may bring a marketing plan to a standstill, but finger-pointing and the stress can turn a pleasant, creative experience into the project from hell.

    The role of the designer

    Designers are hired primarily to create effective, attention-getting designs and to produce pre-press files that printers can use to mass-produce brochures, publications and the like.
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

    Designers are also responsible for bridging the world of the commercial printing and design, helping the client through the complex world of printing specifications, paper selection, soft and hard proofs and getting ink on paper.

    With so many robust graphic design tools on the market such as Adobe Illustrator, Quark XPress, Adobe InDesign, Coral Draw and others, to name a few, creating pre-press files that work flawlessly with any commercial print shop should be a piece of cake, right?

    Well, yes—and no. While many of today's design and pre-press tools are first-rate, they are only part of the overall print production process. It's really up to the designer to make
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    sure all parties involved in any given printing project are all on the same page.

    The importance of communication

    When working with clients, my approach has always been to establish early on in the project what printer will be involved in reproducing the project. Having worked for several offset printing shops early on in my career, I learned that there is always a right way, a wrong way and their way. While the printing industry follows general guidelines and while most printing companies have similar internal pre-press operations, every shop is a little different in their approach and workflow.

    If possible, I try to have a conversation with the client's p
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    rinter right away to determine what pre-press programs they support in native format and what are alternatives to supplying the native files. If my client does not have a printer he or she wants to work with, I will suggest a printer who is a good match for the type of printing needed, and someone I have worked with before and have a working knowledge of or experience with.

    Using PDF files

    In the "good old days" we either submitted to a printer the "native" files or we could submit PostScript files which would contain all the font outlines and layout information, independent of the program used to create the document. But even this approach had it's share of
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    film and plate output problems and if changes needed to be made to the file, the printer had to contact the designer and have the original file corrected and a new PostScript file generated and sent to the printer.

    PDF files potentially can serve as a way to give the printer one file to print from without worrying about fonts, support files, or the printer having the latest versions of the document software, etc. By far the biggest advantage is that both clients and all involved in the project can use Adobe Reader to view and print the project, whereas PostScript files were far less portable and often you didn't know there was a problem until film or plates were pro
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    uced.

    All PDFs are not created equal

    While we live in a world of Adobe PDFs which at first seem to be the perfect solution to printing companies having to keep up with all the various pre-press programs available today, there are different types of PDF files and they are not always the best approach.

    I have been working with the Adobe Creative Suite for some time now and it is relatively easy to create different types of PDFs. Depending on your needs, you can create a client proof or a printing file.

    For example, you can export a PDF from InDesign as a Print PDF, Screen PDF, Press PDF and you can customize the PDF with various options when you save it. Wit
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    h so many options, what is the best way to save the file for your commercial printer?

    The answer is, you have to talk to the printing company you will be sending files to—never assume anything, and always assume that every printer have slightly different requirements.

    Using "Native" Files

    Some designers find it easier to send to their printer the original InDesign, Quark XPress or other layout program file, along with support files. The biggest reason for doing this is that if the client indicates a change to the printer's proof, the printer can make the required change (as long as the overall design is not changed or copy is not reflowed substantially), in
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    tead of the designer being a part of the process.

    If you have ever had a project fall victim to Murphy's Law ("if something can go wrong, it will") and have experienced working with a printer where no matter what fonts you sent, their system didn't want to print your file right, you may want to consider sending the printer InDesign or Illustrator files where the type has been converted to outlines. While this eliminates any font issues, it creates an extra step and if changes to the file need to me made, the designer will have to have a version of the file with all the type intact.

    In some cases, a printer may want your native files instead of PDFs.

    Working wit
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    h the printer

    It's always best to work with an offset printer you have some experience with so you know up front what to expect in terms of proofing, file approval and for dealing with problems that may arise.

    Having some previous experience with a "can do", problem-solving printer can be great when you have a project that pushes the limit of your pre-press and printing knowledge. While printer's may not have a "graphic designer" on staff, they always have several people who are very pre-press savvy and who work with the challenges of trapping, file problems and the like on a daily basis. These professionals can be a great resource for you and will often provid
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    some advice and feedback on a project for free.

    You get what you pay for

    It seems that everyone today is offering rock bottom four-color printing online and it can be tempting for designers and clients to want to go for the lowest possible price advertised. But be careful, often the prices quoted online are not complete quotes—you can end up spending a lot more on a project for proofs, folding, shrink wrapping and other details you assume will be included—which are not.

    Make sure the proof you receive is representational of the project. Some printers provide a "digital" proof, generally an ink jet proof that may or may not be calibrated to their presses. I
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    your project has critical color or you client insists on a proof that will be used by the pressmen to match to, make sure the proof you receive to sign off on is a quality proof.

    Some budget online printers offer "soft proofs" which are merely PDF proofs. While this approach can work well, everyone involved in the approval process has to have their monitor calibrated so that everyone is seeing the same thing and can truly compare apples to apples.

    Some printers force you to go through their special file submission process, so the printer's pre-press system is actually able to check your files automatically and make sure they are compatible with their plate system.
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    While a bit more time-consuming to the designer and sometimes requiring the downloading of "client" software, this approach can alert the designer of any problems before you go to press.

    Making changes

    It happens to all of us--something slips through the cracks and a mistake is found just before a project is scheduled to hit the press. Even after a client has signed off on a design project and released the files to the printer, the proof comes back a few days later from the printer and either a mistake needs to be corrected or something needs to be changed. Meanwhile, the clock is ticking.

    If you send your printer a PDF file to proof and plate from, and th
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    client makes changes to the printer's proof, you will need to go back to your original files, make the changes and submit new PDF files to your printer.

    Most printers will not charge for submitting a second file and creating a second proof, but many do. Be sure to make sure you date the new files or rename them so there will be no confusion between the old files and the new files. Recently, I sent updated files to my printer and they failed to use the latest version.

    Luckily, I had sent the updated file via e-mail and had changed the file name to reflect the fact it was the latest version. The printer admitted they made the error and they reprinted the brochure pr
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    oject at their expense, but having a clear paper trail made this a painless process for me and for my client.

    If the client requests a change that the printer will make to the pre-press files, make sure your client is aware of any additional charges involved. Clients have a way of remembering the exact amount they were quoted for printing and assume the price is all-inclusive.

    Ten Tips for near "fool proof" printing:

    1) Send a hard copy. Send your printer an ink jet proof with all crop and bleed marks, instructions and a mockup showing folds, scores, etc. While it is easy to send files via e-mail and FTP, there is no substitute for a mockup or proof
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    ith clear, written instructions.

    2) Communicate with your printer before starting. Talk to your printer before designing your print project to make sure your design is well within their capabilities. If you have never worked with a particular printer before, find out what size presses your project will go on and make sure you talk through the project with the printer, anything that may be out of the ordinary.

    3) Understand your printer's pre-press workflow. Make sure you understand the printer's pre-press process and what types of proofs are available. Not all proofs are "color correct" so make sure the color proof you receive is a fair representation
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    of what to expect the final printing to look like. Keep in mind that clients may not understand the differences between a proof on ink jet paper and what ink on paper will look like. Sometimes proofs appear more color saturated or have more contrast than the actual printing and clients may be disappointed if they compare the proof to the final printing.

    4) Review printer's proofs carefully. After your client reviews the printer's proof, even if they sign off with no changes, take a few minutes to review the proof and make sure it reflects the latest version of the document. In the rush to get a project to the printer and scheduled for press time, mistakes can
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    happen and old files can be copied t CD Rom or uploaded to the printer.

    5) Proofread behind your client. While most designers require that the client assume all responsibility for proofing a project, it can be helpful to have someone not familiar with the project to read it over. Sometimes a glaring mistake can be found very easily and corrected before it becomes a major disaster.

    6) Check printer's proofs for correct folding and assembly. Make sure the printer's proof you receive scores, folds and trims correctly. If your brochure has a fold in panel that is supposed to be a certain width, make sure it is as it should be, and not an arbitrary or com
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    only folded size.

    7) Allow a reasonable amount of production time for your printer. When working with tight delivery deadlines, make sure you allow the printer enough time to produce proofs and to receive files and schedule printing. Actual printing schedules tend to change day to day, so the final delivery date may not be exactly what was quoted originally. Working with printer you have experience with, you will know if the delivery date they give you and your client is something you can bank on, or not.

    8) Drop ship a partial order when necessary. If you need to get printing to your client for an event, consider sending a partial order via overnight
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    delivery so they can have some of the order right away and the balance in a day or two.

    9) Have a "Plan B" ready. Be prepared to deal with problems that may occur, especially if you are rushing a project to meet a client's deadline. Printers are generally very customer service minded, but are human and sometimes things go wrong. Simply blaming someone else for the problem will not help to resolve it. Our role as designers is often to assist with resolution of problems, so keep a win-win solution in mind and make sure a client is aware that setting unrealistic deadlines for printing is often a recipe for disaster.

    10) Create a paper trail. Make sure y
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    u communicate with all parties involved—both the printer and your client. If possible, send your client carbon copies of e-mails you send to the printer, or at least save all e-mails so if any decision is called into question, you have a clear paper trail. Even if you have clear evidence showing you did what your client instructed, you need to keep in mind the client sees the designer as the printing consultant and is looking for us to make things go smoothly. Keeping the client in the loop will also help them to understand better when problems arise instead of the client being the last to know and feeling they are out of the loop and having little say in the process


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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