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    I was sitting at my desk trying to get inspiration for an edition of a newsletter I write when grandson Tory, who hangs out with me a lot said, 'What's this P
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    op?' He'd been progressively going through the top drawer of my desk and it was about the 10th time I'd answered. It got me thinking about curiosity and how u
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    ncluttered minds remember.

    When we are three like Tory we are very curious about our physical world and the cornucopia of gadgets and animate beings that fil
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    it. It's a period of rapid intellectual development, excitement at every turn, and discovery. My young companion constantly amazes me how he can recall days
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    later, names he has heard once. (I can't even remember where I left my cordless phone half hour beforehand!)

    I encourage (and reward) Tory's curiosity by tak
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    ing time out to demonstrate or discuss the things about which he is curious. For example, when he asked me what a staple puller was, I demonstrated by placing
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    a staple in a sheet of paper and then pulled it out with the staple puller. He may not yet know why we use staples to hold sheets of paper together, but he su
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    re knows that one process places the staple and another removes it.

    As the years pass, we become more selective in what we remember and our curiosity diminis
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    hes to varying degrees. Imagine what we could do as managers if we could inculcate a sense of curiosity in our employees/learners.

    Marketers often use a devi
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    e to arouse curiosity in their readers. And it works. The question is, what devices can we use in our workplaces to develop curiosity in our people?

    An examp
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    le that comes to mind is to implement a suggestion box. I recall an excellent example of how useful suggestion boxes can be from my service in the Royal Austr
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    alian Air Force during the Vietnam War era. While some of our bombs were fitted with devices to make them explode above ground level, it was a hit and miss ap
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    roach … some exploded at the right altitude and others didn't. My boss, an electrical engineer, was curious why this was happening and after looking at the tr
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    iggering mechanism, 'suggested' how it could be improved. His suggestion was adopted and worked. The RAAF sent him a cheque for $3,000 (quite a lot in 1969).
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen

    Rather than having a truck load of suggestion boxes placed here and there within our organizations and hoping someone will place a worthwhile suggestion, I l
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    ke the idea of circulating a list of 'challenges' that need resolving and asking staff to come up with options.

    Management doesn't have all the answers (alth
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    ough many managers believe they do) and quite often the lowest salaried staff can see things that management can't (or see things with a different perspective
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    ).

    If we peak curiosity, imagination and creativity will follow. Rather than having people 'Turn off their brains when they come to work', we want them to 'T
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    rn on their creativity and imagination' and hopefully solve some of our challenges.

    In this rapidly changing and global world, creativity and imagination are
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    the only really viable skills for long term survival. And it's much more fun than anything I can think of that we might call work.

    Copyright 2005 Robin Henr


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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