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Main Subject - How to Know When to Change Air-Conditioning Filters?
Although we don't usually realize it, we can actually reduce the running cost of a building by removing the dust from the atmosphere. The furniture, walls and fittings are pr
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
eserved longer. It also improves the health of the occupants.
Removing dust is usually done by installing filters in the incoming air stream or the circulating air stream. I
Removing dust is usually done by installing filters in the incoming air stream or the circulating air stream. I
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
n air-conditioning systems, these filters are installed at the air handling units or AHU's.
How do we know when to replace the filters?
As more and more dust accumulates at
How do we know when to replace the filters?
As more and more dust accumulates at
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
the filters, the differential pressures between the inlet and the outlet will increase. By measuring the differential pressures, we will have a very good indication of how m
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
ch the filter has been choked by dusts. Persons maintaining the air-conditioning plant should know at what differential a filter should be replaced. Some of the dust particle
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
s are so minute, that they cannot be seen by the naked eye. In all appearances, the filter looks as good as new.
These are some factors to consider when determining when to
These are some factors to consider when determining when to
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
change the filter:
Mechanical strength of the filter
The final pressure of a filter is usually stated in the product. That is the strength of the filtration medium.
Mechanical strength of the filter
The final pressure of a filter is usually stated in the product. That is the strength of the filtration medium.
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
owever, other factors need to be considered - the strength of the filter walls, frames and holders if not adequately designed can result in the sagging of the filter housing
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
that will result in leaks.
Changes in efficiency of the filter
This is particularly important in low efficiency filters. Their efficiencies can be radically impaired
Changes in efficiency of the filter
This is particularly important in low efficiency filters. Their efficiencies can be radically impaired
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
as a result of high final pressure losses. Particles that have been collected by the filter can become detached and accompany the air stream. Fibrous particles are less like
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
y to become detached compared to granular particles. Because of this, higher final pressure drops are permissible for the former, although this should not exceed about 200 Pa
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
in a pre-filter.
With granular particles, the final pressure loss should not be allowed to exceed 100 to 150 Pa.
Fine filters and HEPA filters are less sensitive to change
With granular particles, the final pressure loss should not be allowed to exceed 100 to 150 Pa.
Fine filters and HEPA filters are less sensitive to change
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
s in quality. In principle, they can be allowed to have a final pressure loss up to the limit of their mechanical strength.
Permissible Air flow variations in the system<
Permissible Air flow variations in the system<
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
/b>
In this case, the flow pattern is more important than the particles carried along the air stream. The permissible final pressure loss here will depend on the total press
In this case, the flow pattern is more important than the particles carried along the air stream. The permissible final pressure loss here will depend on the total press
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
re and characteristics of the fan and any other control facilities.
The filter will affect the air flow as a result of dust accumulation. The filter has to be changed when t
The filter will affect the air flow as a result of dust accumulation. The filter has to be changed when t
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
he velocity of the air in a laminar flow installation cannot be maintained or has fallen below the required specifications.
Bacteriological reasons
Sometimes, the fi
Bacteriological reasons
Sometimes, the fi
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
lters are replaced at regular intervals instead of pre-defined pressure loss indications. This is to prevent accumulation of bacteria and other microorganisms.
Suitable t
Suitable t
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
me window periods
Filters are often changed to coincide with pre-planned plant shutdown periods. In these cases, production disturbances are minimized. For example they
Filters are often changed to coincide with pre-planned plant shutdown periods. In these cases, production disturbances are minimized. For example they
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
can be arranged to be changed during holidays.
Economic considerations
In terms of operating costs, there is an optimum final pressure point to balance. By having lo
Economic considerations
In terms of operating costs, there is an optimum final pressure point to balance. By having lo
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
nger intervals between filter replacements, we do achieve lower filter replacement costs. On the other hand, this will increase the operating energy costs due to inefficiency
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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